Acute generalized exanthematous pustulosis - Pustulosis Exanthematous Umum Akut
Pustulosis Exanthematous Umum Akut (Acute generalized exanthematous pustulosis) (AGEP) ialah tindak balas kulit yang jarang berlaku yang dalam 90% kes berkaitan dengan pemberian ubat. pustulosis exanthematous umum akut (acute generalized exanthematous pustulosis) dicirikan oleh letusan kulit secara tiba-tiba yang muncul secara purata lima hari selepas ubat dimulakan. Letusan ini adalah pustula, iaitu letusan kecil merah putih atau merah pada kulit yang mengandungi bahan keruh atau purulen (nanah). Lesi kulit biasanya sembuh dalam masa 1-3 hari selepas menghentikan ubat yang menyinggung perasaan.
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Lesi yang meluas dengan eritema dan pustula muncul secara tiba-tiba.
References
Acute generalized exanthematous pustulosis (AGEP) ialah tindak balas kulit yang ditandai dengan benjolan kecil berisi nanah pada pangkal kulit merah. Ia biasanya berlaku apabila seseorang mengambil ubat tertentu, seperti antibiotik, dan merebak dengan cepat ke seluruh badan. Selepas menghentikan ubat yang mencetuskan, gejala biasanya hilang dalam masa dua minggu, selalunya meninggalkan beberapa penumpahan kulit. Walaupun biasanya tidak serius dan terhad kepada kulit, kes yang teruk boleh diklasifikasikan bersama dengan tindak balas kulit serius yang lain seperti Stevens-Johnson syndrome atau toxic epidermal necrolysis. Rawatan adalah terutamanya penjagaan sokongan, dan prognosis untuk penyelesaian lengkap penyakit ini biasanya sangat baik.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Seorang lelaki berusia 76 tahun datang ke bilik kecemasan kerana kulitnya telah berubah sejak dua hari lalu. Doktor menemui tompokan merah dan kawasan terangkat pada batang dan lengan serta kakinya. Lama kelamaan, tompok-tompok ini bercantum, dan dia membentuk benjolan seperti jerawat di kawasan merah. Ujian menunjukkan bilangan sel darah putih yang tinggi dengan banyak jenis yang dipanggil neutrofil, dan peningkatan tahap C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
